Hepatitis News : Interferon-Free Hep C Treatment With Faldaprevir is Safe & Effective
A Smart + Strong Site
Subscribe to:
Hepatitis E-newsletter
Join Us:

Back to home » Hepatitis News » November 2012


emailprint

November 27, 2012

Interferon-Free Hep C Treatment With Faldaprevir is Safe & Effective

A new, interferon-free combination therapy with faldaprevir (BI 201335), a next-wave protease inhibitor, and BI 207127, a non-nucleoside polymerase inhibitor, is safe and effective among people with hepatitis C virus (HCV), including those with advanced liver disease. Representatives from Boehringer Ingelheim presented the Phase IIb results of their SOUND-C2 study at the annual meeting of the American Association for the Study of Liver Diseases in Boston. This is the first paper to report on interferon-free treatments among patients with compensated cirrhosis.

Researchers recruited 362 hep C patients, 33 of whom had liver cirrhosis, for the open-label study, dividing them into five treatment arms. Each of the arms took 120 milligrams of faldaprevir once a day with one of the following:

  • 600 mg of BI 207127 three times a day, plus ribavirin for either 16, 28 or 40 weeks.
  • 600 mg of BI 207127 twice a day, with or without ribavirin for 28 weeks.
Patients with cirrhosis experienced sustained virologic response (SVR, considered a cure) rates between 43 and 80 percent for those taking regimens containing ribavirin, depending on their HCV sub-genotype and IL28B host genotype.

Among the total patient population, between 52 and 69 percent achieved an SVR 24 weeks after completing therapies containing ribavirin and 39 percent in the arm without ribavirin. The regimens proved well-tolerated, with only 8 percent of patients stopping treatment because of serious side effects, most of which the researchers deduced were not related to the antivirals. Boehringer Ingelheim will soon begin a Phase III trial of these investigative agents.

To read the aidsmap report, click here.

To read the Boehringer Ingelheim release, click here.

Search: hepatitis C, interferon-free, combination therapy, safe and effective, protease inhibitor, BI 207127, non-nucleoside polymerase inhibitor, HCV, virus, advanced liver disease, Boehringer Ingleheim, Phase IIb, SOUND-C@, cirrhosis, open-label styd, fadaprevir, ribavirin, sustained virologic response, SVR, IL28B host genotype, side effects.


Scroll down to comment on this story. Click here to visit the Hep Forums and ask questions about this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The Hep team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (4 total)


[Go to top]

Quick Links
Current Issue
Forums
Poll
Blogs
Hep TV
Calendar
Services Directory
Conference News
Top Stories
Treatment News
Hep Exclusives
All About Hepatitis
• Hepatitis A
Transmission
Prevention
Treatment
• Hepatitis B
Transmission
Prevention
Treatment
• Hepatitis C
Transmission
Prevention
Treatment
HCV/HIV Coinfection
Help Paying For Meds
Clinical Trials
TALK TO US
Tell us what you think
Poll
Are you planning to do anything for World Hepatitis Day on July 28?
Yes
No


Survey
Hepatitis C Reader Survey
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.