Hepatitis C Treatment : Hepatitis C Re-Treatment Recommendations
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Hepatitis C Re-Treatment Recommendations

If you have been treated for HCV before, here are the recommendations for re-treatment for all genotypes from the American Association for the Study of Liver Diseases (AASLD) and Infectious Diseases Society of America (IDSA):

AASLD HCV Re-treatment Recommendations for Patients Who Failed Prior Peginterferon and Ribavirin Treatment
Recommended Alternative
Genotype 1a
(no cirrhosis)
Harvoni for 12 weeks
OR
Olysio + Sovaldi for 12 weeks
OR
Viekira Pak + ribavirin for 12 weeks
n/a
Genotype 1a
(with compensated cirrhosis)
Harvoni for 24 weeks
OR
Harvoni + ribavirin for 12 weeks
OR
Olysio + Sovaldi with/without ribavirin for 24 weeks without Q80K polymorphism
OR
Viekira Pak + ribavirin for 24 weeks
n/a
Genotype 1b
(no cirrhosis)
Harvoni for 12 weeks
OR
Olysio + Sovaldi for 12 weeks
OR
Viekira Pak for 12 weeks
n/a
Genotype 1b
(with compensated cirrhosis)
Harvoni for 24 weeks
OR
Harvoni + ribavirin for 12 weeks
OR
Olysio + Sovaldi with/without
ribavirin for 24 weeks
OR
Viekira Pak + ribavirin for 12 weeks
n/a
Genotype 2 Sovaldi + ribavirin for 12 to 16 weeks Sovaldi + ribavirin + PEG** for 12 weeks
Genotype 3Sovaldi + ribavirin + PEG** for 12 weeks Sovaldi + ribavirin for 24 weeks
Genotype 3
(Failed prior treatment with Sovaldi + ribavirin)
Sovaldi + ribavirin + PEG** for 12 weeks n/a
Genotype 4 Harvoni for 12 weeks
OR
Sovaldi + ribavirin + PEG** for 12 weeks
OR
Sovaldi + ribavirin for 24 weeks
OR
Viekira Pak (without dasabuvir)
+ ribavirin for 12 weeks
n/a
Genotype 5 Harvoni for 12 weeks Sovaldi + ribavirin + PEG** for 12 weeks
Genotype 6 Harvoni for 12 weeks Sovaldi + ribavirin + PEG** for 12 weeks


AASLD HCV Re-treatment Recommendations for Patients Who Failed Prior Treatment  with Sovaldi (sofosbuvir) + Ribavirin, with/without PEG**
Recommended Alternative
Genotype 1
(no cirrhosis)
Harvoni + ribavirin for 12 weeks n/a
Genotype 1
(with cirrhosis)
Harvoni + ribavirin for 24 weeks n/a


AASLD HCV Re-treatment Recommendations for Patients Who Failed Prior Treatment with Peginterferon, Ribavirin, and an HCV Protease Inhibitor (Incivek, Olysio, Victrelis) or Failed Olysio + Sovaldi
Recommended Alternative
Genotype 1
(no cirrhosis)
Harvoni for 12 weeks Harvoni + ribavirin for 12 weeks if failed prior treatment with Olysio + Sovaldi
Genotype 1
(with cirrhosis)
Harvoni for 24 weeks
OR
Harvoni + ribavirin for 12 weeks (not recommended for cirrhotic patients who previously failed Olysio + Sovaldi)
Harvoni + ribavirin for 24 weeks if failed prior treatment with Olysio + Sovaldi


* When more than one treatment is recommended, they are listed alphabetically
** PEG = peginterferon


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Last Revised: July 24, 2015

This content is written by the Hep editorial team.

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