Hepatitis C Treatment : Hepatitis C Treatment-Naive Recommendations
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Hepatitis C Treatment-Naive Recommendations

If this is your first time being treated for HCV (treatment-naive), here are the recommendations for all genotypes from the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA):

AASLD HCV Treatment Recommendations
for Treatment-Naive Patients
Recommended* Alternative
Genotype 1a Harvoni for 12 weeks**
OR
Olysio + Sovaldi for 12 weeks (no cirrhosis)
or 24 weeks with/without ribavirin (cirrhosis without Q80K polymorphism)
OR
Viekira Pak + ribavirin for 12 weeks (no cirrhosis)
or 24 weeks with/without ribavirin (cirrhosis)
n/a
Genotype 1b Harvoni for 12 weeks**
OR
Olysio + Sovaldi for 12 weeks (no cirrhosis)
or 24 weeks with/without ribavirin (cirrhosis)
OR
Viekira Pak for 12 weeks
(+ ribavirin with cirrhosis)
n/a
Genotype 2 Sovaldi + ribavirin for 12 weeks
(16 weeks with cirrhosis)
none
Genotype 3 Sovaldi + ribavirin + PEG*** for 12 weeks Sovaldi + ribavirin for 24 weeks
Genotype 4 Harvoni for 12 weeks
OR
Sovaldi + ribavirin for 24 weeks
OR
Viekira Pak (without dasabuvir) +
ribavirin for 12 weeks

Olysio + Sovaldi with/without
ribavirin for 12 weeks
OR
Sovaldi + ribavirin + PEG*** for 12 weeks
Genotype 5 Harvoni for 12 weeks Sovaldi + ribavirin + PEG*** for 12 weeks
Genotype 6 Harvoni for 12 weeks Sovaldi + ribavirin + PEG*** for 12 weeks


* When more than one treatment is recommended, they are listed alphabetically
** 8 weeks may be considered in patients without cirrhosis who have pre-treatment HCV RNA less than 6 million IU/mL
*** PEG = peginterferon


For more information about the different classes of HCV treatment and a list of approved HCV treatment, click here.

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Last Revised: July 24, 2015

This content is written by the Hep editorial team.

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