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Nucleotide NS5B Polymerase Inhibitors

*generic version available

E experimental


DRUG Sovaldi
GENERIC NAME sofosbuvir
COMPANY Gilead Sciences

What are Nucleotide NS5B Polymerase Inhibitors?

These drugs block the NS5B protein, which plays a role in the replication of HCV and is involved in creating copies of the viral RNA genome. Sovaldi is used to treat HCV genotypes 1, 2, 3 and 4 and is part of a once-a-day combination pill with the NS5A inhibitor ledipasvir. Sovaldi may also be combined with other drugs, such as Daklinza, Olysio, or ribavirin, depending on various factors.

Last Reviewed: March 29, 2018


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