This isn’t a typical experience. The question I’d ask my doctor is, “Are these side effects caused by the hepatitis C treatment or something else?” Although it makes sense to assume that any health changes are medication related, that isn’t always the case. Sometimes people develop an unrelated health problem while they are taking hepatitis C medications.
Although fatigue is a common side effect of Harvoni (sofosbuvir/ledipasvir), weight gain is not—particularly that much and that quickly. Hair loss, fatigue and weight gain can be symptoms of other diseases, such as a thyroid condition. Report your symptoms to the specialist overseeing your hepatitis C treatment, as well as your primary care provider. Follow this link for additional tips on how to manage side effects.