Generally, the new hepatitis C direct-acting antivirals are much easier to tolerate than the older interferon-based treatments. The likelihood and intensity of side effects depend on what hepatitis C treatment is prescribed. If ribavirin is included, then people typically notice more side effects. When ribavirin isn’t prescribed, some people have few or no side effects.
For whatever reason, some people just seem to experience more side effects even with the easier to tolerate treatments. Fatigue is the most common issue. Your medical provider can help you manage side effects, especially if you report them early. Follow this link for additional tips on how to manage side effects.