Curing hepatitis C virus (HCV) is associated with a reduction in portal vein pressure, or portal hypertension, which causes some of the most serious complications of liver cirrhosis, reports. Publishing their findings in the Journal of Hepatology, researchers conducted a retrospective analysis of 104 people with hep C and portal hypertension, defined as having a hepatic venous gradient measurement (HPVG) of at least 6 millimeters of mercury (mmHg).

All participants received HPVG and liver stiffness testing before hep C treatment. One hundred people in the study were cured; of that group, 60 underwent additional HVPG and liver stiffness tests after finishing treatment and post-treatment follow-up to determine whether they were cured.

Curing hep C lowered portal pressure regardless of its initial severity. Those who started with 6 to 9 mmHg saw an average drop of 2.26 mmHg; those who started with 10 to 15 mmHg saw an average drop of 3.29; and those who started with at least 16 mmHg saw an average drop of 2.3.

Those who had Child-Pugh stage B liver disease were 90 percent less likely to experience a decrease in their HVPG compared with those with the milder Child-Pugh stage A liver disease.

To read the HIVandHepatitis article, click here.

To read the study abstract, click here.