and buprenorphine are medications to prevent withdrawal from, and treat
dependence on, narcotics. Hepatitis C is very common among people on opioid
substitution treatment (OST) with methadone or buprenorphine.
increases adherence to HIV treatment by stabilizing people; the same is true
for hepatitis C treatment. HCV has been safely treated—and cured—in people on
buprenorphine and methadone. In fact, methadone clinics are an ideal place for
HCV support groups and directly observed, multidisciplinary hepatitis C
treatment programs, since people must show up regularly to get their methadone.
on OST should be carefully monitored during hepatitis C treatment. Methadone
dosing may need to be adjusted, even in the absence of a known or suspected
drug-drug interaction. This is because some people experience similar side
effects from pegylated interferon and drug withdrawal; increasing the dose of
methadone has helped manage these side effects.
Drug-drug interactions between HCV
protease inhibitors and methadone or buprenorphine may complicate hepatitis C